/* Pyrinome Therapeutics — site styles */
@font-face{font-family:'Inter';font-style:normal;font-weight:100 900;font-display:swap;src:url(assets/fonts/inter.woff2) format('woff2')}
@font-face{font-family:'Source Serif 4';font-style:normal;font-weight:200 900;font-display:swap;src:url(assets/fonts/source-serif-4.woff2) format('woff2')}
@font-face{font-family:'Source Serif 4';font-style:italic;font-weight:200 900;font-display:swap;src:url(assets/fonts/source-serif-4-italic.woff2) format('woff2')}
:root{
  --navy:#0d2230;
  --navy-2:#132f40;
  --ink:#14262f;
  --muted:#55656d;
  --soft:#7d8b92;
  --accent:#e2361b;
  --accent-2:#f55b0b;
  --line:#e1e6e8;
  --pale:#f4f6f7;
  --paper:#ffffff;
  --serif:'Source Serif 4',Georgia,'Times New Roman',serif;
  --sans:'Inter',-apple-system,BlinkMacSystemFont,'Segoe UI',Arial,Helvetica,sans-serif;
  --wrap:1200px;
  --radius:10px;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth;scroll-padding-top:84px}
body{margin:0;color:var(--ink);font-family:var(--sans);font-size:17px;line-height:1.7;background:var(--paper);-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility}
img{max-width:100%}
a{color:inherit;text-decoration:none}
a:focus-visible,summary:focus-visible{outline:3px solid var(--accent);outline-offset:5px;border-radius:2px}
.skip{position:absolute;left:20px;top:-100px;background:#fff;padding:12px 16px;z-index:50;border-radius:6px}
.skip:focus{top:10px}
.wrap{max-width:var(--wrap);margin:0 auto;padding-left:40px;padding-right:40px}

/* Header */
.site-header{position:sticky;top:0;z-index:20;background:rgba(255,255,255,.92);backdrop-filter:saturate(1.6) blur(12px);-webkit-backdrop-filter:saturate(1.6) blur(12px);border-bottom:1px solid rgba(13,34,48,.08)}
.header-inner{height:84px;display:flex;align-items:center;justify-content:space-between;gap:24px}
.brand{display:flex;align-items:center}
.logo{display:block;width:150px;height:74px;object-fit:contain;object-position:left center}
.site-header nav{display:flex;gap:6px;font-size:14px;font-weight:500}
.site-header nav a{padding:8px 14px;border-radius:999px;color:var(--ink);transition:background .2s,color .2s}
.site-header nav a:hover{background:var(--pale);color:var(--accent)}

/* Type */
.eyebrow{font-size:12px;font-weight:600;letter-spacing:.16em;text-transform:uppercase;color:var(--accent);margin:0 0 22px;display:flex;align-items:center;gap:12px}
.eyebrow::before{content:"";width:28px;height:2px;background:linear-gradient(90deg,var(--accent-2),var(--accent));border-radius:2px}
h1,h2{font-family:var(--serif);font-weight:500;letter-spacing:-.02em;line-height:1.1;margin:0 0 28px}
h1{font-size:clamp(38px,4.2vw,60px)}
h2{font-size:clamp(32px,3.6vw,50px)}
h3{font-size:19px;line-height:1.35;font-weight:600;margin:0 0 8px;letter-spacing:-.01em}
sup{font-size:11px;line-height:0}
sup a{color:var(--accent);padding:0 2px;font-weight:600}
sup a:hover{text-decoration:underline}

/* Buttons */
.button{display:inline-flex;align-items:center;gap:10px;background:linear-gradient(135deg,var(--accent-2),var(--accent));color:#fff;padding:14px 26px;font-size:15px;font-weight:600;border-radius:999px;box-shadow:0 8px 24px -8px rgba(226,54,27,.6);transition:transform .2s,box-shadow .2s}
.button:hover{transform:translateY(-1px);box-shadow:0 12px 28px -8px rgba(226,54,27,.75)}
.button span{transition:transform .2s}
.button:hover span{transform:translateX(3px)}
.text-link{font-size:15px;font-weight:600;color:#fff;border-bottom:1px solid rgba(255,255,255,.35);padding-bottom:2px;transition:border-color .2s}
.text-link:hover{border-color:#fff}

/* Hero */
.hero{position:relative;overflow:hidden;color:#fff;background:
  radial-gradient(900px 520px at 82% 38%,rgba(245,91,11,.20),transparent 60%),
  radial-gradient(700px 500px at 0% 100%,rgba(38,92,120,.35),transparent 60%),
  linear-gradient(160deg,#0f2939 0%,var(--navy) 55%,#0a1b26 100%)}
.hero::after{content:"";position:absolute;inset:0;background-image:radial-gradient(rgba(255,255,255,.06) 1px,transparent 1px);background-size:26px 26px;mask-image:linear-gradient(180deg,transparent,#000 30%,#000 70%,transparent);-webkit-mask-image:linear-gradient(180deg,transparent,#000 30%,#000 70%,transparent);pointer-events:none}
.hero .wrap{position:relative;z-index:1}
.hero-grid{display:grid;grid-template-columns:1.3fr 1fr;gap:56px;align-items:center;padding-top:110px;padding-bottom:40px;min-height:600px}
.hero .eyebrow{color:#ff8a5c}
.hero h1{color:#fff}
.lead{font-size:21px;line-height:1.6;max-width:540px;color:rgba(255,255,255,.75);margin:0 0 38px}
.hero-actions{display:flex;align-items:center;gap:30px;flex-wrap:wrap}
.hero-visual{text-align:center}
.hero-mark{position:relative;width:100%;max-width:480px;aspect-ratio:1;margin:0 auto 10px;display:grid;place-items:center}
.hero-mark::before{content:"";position:absolute;inset:18%;border-radius:50%;background:radial-gradient(circle,rgba(245,91,11,.22),transparent 70%)}
.rings{position:absolute;inset:0;width:100%;height:100%;opacity:.85;animation:spin 140s linear infinite}
.hero-logo{position:relative;width:84%;height:auto;filter:drop-shadow(0 10px 30px rgba(0,0,0,.35))}
.hero-visual p{font-family:var(--serif);font-size:19px;line-height:1.5;color:rgba(255,255,255,.8);margin:0;font-style:italic}
@keyframes spin{to{transform:rotate(360deg)}}
.hero-foot{display:flex;gap:48px;padding:26px 0 30px;border-top:1px solid rgba(255,255,255,.12);font-size:14px;color:rgba(255,255,255,.7);margin-top:30px}
.hero-foot span{display:flex;align-items:center;gap:10px}
.hero-foot span::before{content:"";width:8px;height:8px;border-radius:50%;background:var(--accent-2);box-shadow:0 0 0 4px rgba(245,91,11,.2)}

/* Sections */
.section{padding:112px 0}
.split{display:grid;grid-template-columns:5fr 7fr;gap:72px;align-items:start}
.split h2{margin:0}
.body p{margin:0 0 20px;color:var(--muted);max-width:640px}
.body .large{font-family:var(--serif);font-size:25px;line-height:1.45;color:var(--ink);margin-bottom:26px}

/* Approach comparison */
.compare{display:grid;grid-template-columns:1fr 1fr;gap:24px;margin-top:64px}
.compare article{padding:30px 32px;border:1px solid var(--line);border-radius:var(--radius);background:var(--paper)}
.compare h3{font-family:var(--serif);font-weight:500;font-size:22px;line-height:1.4;margin:0}
.compare-label{font-size:12px;font-weight:600;letter-spacing:.12em;text-transform:uppercase;color:var(--soft);margin:0 0 12px}
.compare .ours{background:linear-gradient(135deg,#fff6f1,#fff);border-color:#f6cbb8;position:relative}
.compare .ours .compare-label{color:var(--accent)}

/* Etiostat */
.product{background:var(--pale)}
.product-name{font-size:clamp(64px,8vw,108px);font-weight:500;letter-spacing:-.03em;margin:0 0 18px!important;background:linear-gradient(135deg,var(--accent-2),var(--accent) 60%);-webkit-background-clip:text;background-clip:text;color:var(--accent);-webkit-text-fill-color:transparent}
.product-sub{font-family:var(--serif);font-size:23px;line-height:1.45;color:var(--ink);margin:0}
.ip{margin:34px 0 0;padding:26px 28px;background:var(--paper);border:1px solid var(--line);border-left:3px solid var(--accent);border-radius:var(--radius)}
.ip h3{font-size:13px;letter-spacing:.12em;text-transform:uppercase;color:var(--ink)}
.ip p{margin:0}
.body .key{color:var(--ink);font-weight:500;border-left:3px solid var(--accent);padding-left:18px}
.body .note{font-size:14px;line-height:1.6;color:var(--soft);margin-top:26px}

/* IP */
.ip-block{margin-top:88px;padding-top:72px;border-top:1px solid #d9e0e3;display:grid;grid-template-columns:5fr 7fr;gap:72px;align-items:start}
.ip-head h2{margin-bottom:22px}
.ip-intro{color:var(--muted);margin:0;font-size:17px}
.ip-layers{list-style:none;margin:0;padding:0;display:flex;flex-direction:column;gap:14px;position:relative}
.ip-layers li{display:grid;grid-template-columns:48px 1fr;gap:6px 22px;align-items:start;background:var(--paper);border:1px solid var(--line);border-radius:var(--radius);padding:26px 28px;position:relative}
.ip-layers li:nth-child(2){margin-left:28px}
.ip-layers li:nth-child(3){margin-left:56px}
.ip-layers li:first-child{border-color:#f6cbb8;box-shadow:0 18px 40px -28px rgba(226,54,27,.55)}
.ip-num{width:48px;height:48px;border-radius:50%;display:grid;place-items:center;font-family:var(--serif);font-size:22px;color:#fff;background:linear-gradient(135deg,var(--accent-2),var(--accent))}
.ip-layers li:nth-child(2) .ip-num{background:var(--navy-2)}
.ip-layers li:nth-child(3) .ip-num{background:#4a6472}
.ip-kind{font-size:12px;font-weight:600;letter-spacing:.12em;text-transform:uppercase;color:var(--accent);margin:0 0 6px}
.ip-layers h3{font-family:var(--serif);font-weight:500;font-size:21px;line-height:1.3;margin:0 0 8px}
.ip-layers li p:not(.ip-kind):not(.ip-status){font-size:15px;line-height:1.65;color:var(--muted);margin:0}
.ip-status{grid-column:2;justify-self:start;margin:10px 0 0;font-size:12px;font-weight:600;white-space:nowrap;color:#1d5b3b;background:#e6f3ec;border-radius:999px;padding:5px 12px}
.ip-layers li:nth-child(3) .ip-status{color:#7a4a00;background:#fbf0dc}

/* Burden */
.burden h2{max-width:780px}
.burden-scale,.burden-surgery{display:grid;gap:24px;margin-top:24px}
.burden-scale{grid-template-columns:1fr 1fr;margin-top:56px}
.burden-surgery{grid-template-columns:repeat(3,1fr)}
.burden article{background:var(--pale);border-radius:var(--radius);padding:34px 32px 30px;position:relative;overflow:hidden}
.burden article::before{content:"";position:absolute;left:0;top:0;right:0;height:3px;background:linear-gradient(90deg,var(--accent-2),var(--accent))}
.burden strong{font-family:var(--serif);font-weight:500;font-size:54px;line-height:1.05;letter-spacing:-.02em;display:block;margin-bottom:18px;color:var(--accent)}
.burden-scale strong{font-size:60px}
.burden article h3{font-size:17px}
.burden article p{font-size:15px;line-height:1.65;color:var(--muted);margin:0}
.stat-note{font-size:14px;color:var(--soft);margin:26px 0 0;max-width:900px}
.unmet{margin-top:56px;background:var(--navy);color:#fff;border-radius:16px;padding:48px 52px;display:grid;grid-template-columns:1.25fr 1fr;gap:56px;align-items:center;background-image:radial-gradient(500px 300px at 100% 0%,rgba(245,91,11,.18),transparent 70%)}
.unmet h3{font-family:var(--serif);font-weight:500;font-size:27px;line-height:1.3;margin-bottom:16px}
.unmet p{color:rgba(255,255,255,.75);margin:0;font-size:16px}
.unmet sup a{color:#ff8a5c}
.bars{display:flex;flex-direction:column;gap:16px}
.bar-row{display:grid;grid-template-columns:96px 1fr 44px;align-items:center;gap:14px;font-size:14px}
.bar-label{color:rgba(255,255,255,.75)}
.bar{height:12px;background:rgba(255,255,255,.1);border-radius:99px;overflow:hidden}
.bar i{display:block;height:100%;border-radius:99px;background:linear-gradient(90deg,var(--accent-2),var(--accent))}
.bar-row:nth-child(2) .bar i{background:rgba(255,255,255,.7)}
.bar-val{font-weight:600;text-align:right}
.bar-cap{font-size:12px;color:rgba(255,255,255,.5);margin-top:4px}
.sources{font-size:14px;color:var(--muted);margin-top:40px;border-top:1px solid var(--line);border-bottom:1px solid var(--line)}
.sources summary{cursor:pointer;color:var(--ink);font-weight:600;padding:18px 0;list-style:none;display:flex;justify-content:space-between;align-items:center}
.sources summary::-webkit-details-marker{display:none}
.sources summary::after{content:"+";font-size:22px;font-weight:400;color:var(--accent);transition:transform .2s}
.sources[open] summary::after{transform:rotate(45deg)}
.sources ol{margin:0 0 20px;padding-left:22px}
.sources li{margin:12px 0;padding:4px 8px;border-radius:6px}
.sources a{color:var(--ink);text-decoration:underline;text-decoration-color:rgba(226,54,27,.4);text-underline-offset:3px}
.sources a:hover{text-decoration-color:var(--accent)}
.sources li:target{background:#fff1e6}

/* Focus */
.focus{background:var(--navy);color:#fff;background-image:radial-gradient(700px 400px at 0% 0%,rgba(245,91,11,.16),transparent 65%),radial-gradient(600px 400px at 100% 100%,rgba(38,92,120,.35),transparent 65%)}
.focus .eyebrow{color:#ff8a5c}
.focus h2{color:#fff}
.focus .body p{color:rgba(255,255,255,.72)}
.focus .body .large{color:#fff}

/* Team */
.team-head{display:grid;grid-template-columns:1fr;gap:22px}
.team-head h2{margin:0}
.team-intro{color:var(--muted);margin:0;max-width:640px;font-size:18px}
.people{display:grid;grid-template-columns:1fr 1fr;gap:24px;margin-top:56px}
.people article{display:grid;grid-template-columns:116px 1fr;gap:26px;padding:28px;border:1px solid var(--line);border-radius:var(--radius);background:var(--paper);transition:border-color .2s,box-shadow .2s,transform .2s}
.people article:hover{border-color:#d3dade;box-shadow:0 18px 40px -24px rgba(13,34,48,.35);transform:translateY(-2px)}
.people img{width:116px;height:140px;object-fit:cover;object-position:center top;border-radius:8px;filter:grayscale(1) contrast(1.05);background:var(--pale);transition:filter .3s}
.people article:hover img{filter:grayscale(0)}
.people h3{font-size:19px;margin:0}
.people p{font-size:15px;line-height:1.65;color:var(--muted);margin:10px 0 0}
.people .credentials{font-size:12.5px;margin:3px 0 0;color:var(--soft);letter-spacing:.04em}
.people .role{display:inline-block;color:var(--accent);font-weight:600;font-size:12.5px;letter-spacing:.06em;text-transform:uppercase;margin-top:10px}

/* Footer */
.site-footer{background:#0a1b26;color:rgba(255,255,255,.7);font-size:14px;padding:72px 0 0}
.footer-inner{display:flex;justify-content:space-between;align-items:flex-start;gap:48px;padding-bottom:48px}
.footer-brand img{width:150px;display:block;margin-bottom:18px}
.footer-brand p{margin:0;line-height:1.6;font-size:15px}
.site-footer nav{display:flex;gap:10px 36px;flex-wrap:wrap;padding-top:8px}
.site-footer nav a:hover{color:#fff}
.footer-legal{display:flex;justify-content:space-between;gap:24px;flex-wrap:wrap;padding-top:24px;padding-bottom:32px;position:relative}
.footer-legal::before{content:"";position:absolute;top:0;left:40px;right:40px;height:1px;background:rgba(255,255,255,.1)}
.footer-legal p{margin:0}
.footer-legal .fine{font-size:13px;color:rgba(255,255,255,.5)}

/* Responsive */
@media(max-width:1024px){
  .site-header nav a{padding:8px 10px}
  .hero-grid{grid-template-columns:1fr 280px;gap:40px}
  .split,.team-head{gap:48px}
  .unmet{grid-template-columns:1fr;gap:32px}
}
@media(max-width:860px){
  .wrap{padding-left:24px;padding-right:24px}
  .footer-legal::before{left:24px;right:24px}
  .header-inner{height:auto;flex-direction:column;align-items:stretch;gap:0;padding-top:6px}
  .brand{justify-content:center}
  .logo{width:104px;height:52px;object-position:center}
  .site-header nav{justify-content:center;flex-wrap:wrap;gap:0 2px;padding-bottom:8px;font-size:13px}
  .site-header nav::-webkit-scrollbar{display:none}
  .site-header nav a{white-space:nowrap;padding:6px 10px}
  html{scroll-padding-top:120px}
  .hero-grid{grid-template-columns:1fr;min-height:0;padding-top:72px;padding-bottom:16px}
  .hero-visual{order:-1}
  .hero-visual p{display:none}
  .hero-mark{max-width:300px;margin:-20px auto -30px}
  .section{padding:80px 0}
  .split,.team-head,.ip-block{grid-template-columns:1fr;gap:28px}
  .ip-block{margin-top:64px;padding-top:56px}
  .ip-layers li:nth-child(n){margin-left:0}
  .compare{grid-template-columns:1fr;margin-top:44px;gap:16px}
  .burden-surgery{grid-template-columns:1fr 1fr}
  .people{grid-template-columns:1fr}
  .footer-inner{flex-direction:column}
}
@media(max-width:600px){
  .wrap{padding-left:18px;padding-right:18px}
  .footer-legal::before{left:18px;right:18px}
  body{font-size:16px}
  .team-head h2 br{display:none}
  h1{font-size:40px}
  .lead{font-size:18px}
  .hero-foot{flex-direction:column;gap:12px;font-size:13px}
  .section{padding:64px 0}
  .body .large{font-size:21px}
  .compare article{padding:24px}
  .burden-scale,.burden-surgery{grid-template-columns:1fr;gap:16px}
  .burden-scale strong,.burden strong{font-size:46px}
  .burden article{padding:28px 24px 24px}
  .unmet{padding:32px 24px;border-radius:12px}
  .unmet h3{font-size:23px}
  .people article{grid-template-columns:84px 1fr;gap:18px;padding:22px}
  .ip-layers li{grid-template-columns:40px 1fr;gap:16px;padding:22px 20px}
  .ip-num{width:40px;height:40px;font-size:19px}
  .ip-status{grid-column:2;justify-self:start}
  .people img{width:84px;height:104px}
  .footer-legal{flex-direction:column;gap:8px}
}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}.rings{animation:none}*{transition:none!important}}
@media print{
  .site-header{position:static}
  .hero,.focus,.unmet,.site-footer{background:#fff!important;color:var(--ink)!important}
  .hero h1,.focus h2,.focus .body .large{color:var(--ink)}
  .hero-visual,.button,.text-link,nav{display:none}
  .section{break-inside:avoid-page;padding:40px 0}
}

/* Mechanism */
.mech{margin-top:88px;padding-top:72px;border-top:1px solid #d9e0e3}
.mech-head{max-width:780px}
.mech-head h2{margin-bottom:22px}
.mech-figure{margin:48px 0 0;background:var(--paper);border:1px solid var(--line);border-radius:var(--radius);padding:32px}
.mech-figure svg{display:block;width:100%;height:auto;font-family:var(--sans)}
.mech-figure figcaption{font-size:14px;line-height:1.6;color:var(--soft);margin-top:22px;padding-top:18px;border-top:1px solid var(--line)}
.mech-steps{list-style:none;margin:24px 0 0;padding:0;display:grid;grid-template-columns:repeat(4,1fr);gap:16px}
.mech-steps li{display:grid;grid-template-columns:32px 1fr;gap:14px;background:var(--paper);border:1px solid var(--line);border-radius:var(--radius);padding:22px}
.mech-steps li>span{width:32px;height:32px;border-radius:50%;display:grid;place-items:center;font-weight:700;font-size:14px;color:#fff;background:linear-gradient(135deg,var(--accent-2),var(--accent))}
.mech-steps h3{font-size:16px;margin:4px 0 6px}
.mech-steps p{font-size:14px;line-height:1.6;color:var(--muted);margin:0}
.mech-compare{margin-top:24px}
.mech-compare p:not(.compare-label){font-size:15px;line-height:1.65;color:var(--muted);margin:10px 0 0}
@media (max-width:980px){.mech-steps{grid-template-columns:1fr 1fr}}
@media (max-width:640px){.mech{margin-top:56px;padding-top:48px}.mech-figure{padding:14px}.mech-steps,.mech-compare{grid-template-columns:1fr}}